[HTML][HTML] A molecular biopsy test based on arteriolar under-hyalinosis reflects increased probability of rejection related to under-immunosuppression
G Einecke, J Reeve, PF Halloran - American Journal of Transplantation, 2018 - Elsevier
Calcineurin inhibitor immunosuppressive drugs induce changes such as arteriolar
hyalinosis (ah) in kidney transplants, raising the possibility that molecular changes in
biopsies related to histologic ah can provide information about drug exposure. We
hypothesized that molecular changes associated with less-than-expected hyalinosis might
highlight a subpopulation of patients with under-immunosuppression/nonadherence at
intermediate times of biopsy posttransplant (TxBx). Using gene expression data from 562 …
hyalinosis (ah) in kidney transplants, raising the possibility that molecular changes in
biopsies related to histologic ah can provide information about drug exposure. We
hypothesized that molecular changes associated with less-than-expected hyalinosis might
highlight a subpopulation of patients with under-immunosuppression/nonadherence at
intermediate times of biopsy posttransplant (TxBx). Using gene expression data from 562 …
